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KMID : 0352720090330040305
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Journal of Ginseng Research
2009 Volume.33 No. 4 p.305 ~ p.310
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Enhanced Protective Effect of Ultrafine Particles of Red-Ginseng against Phenanthrene-induced Cell Damage
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Seo Yoo-Na
Lee Mi-Young
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Abstract
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Phenanthrene, one of the polycyclic aromatic hydrocarbons, has been known to be toxic to the environment. In this investigation, the protective effect of red ginseng on phenanthrene-induced oxidative DNA damage was evaluated using Comet assay in A549 cells. Red ginseng’s cytoprotective effect on phenanthrene-induced hemolysis was also investigated. This study’s findings show that oxidative DNA damage and hemolysis were significantly prevented by red ginseng treatment. Notably, it was found that pulverizing red ginseng into ultra-fine particles even enhanced its protective effects against DNA damage and hemolysis. The results suggest that particle size reduction seems to effectively enhance red ginseng’s pharmacological efficacies.
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KEYWORD
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red ginseng, particle size reduction, cytoprotection, phenanthrene
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